Scientist, Delivery Sciences Lipid Chemistry

What you'll do - Design new ionizable lipids and lipid conjugates for antibodies, peptides, and other targeting moieties across multiple structural families, pushing the platform beyond current-generation materials. - Devise and execute practical synthetic routes to priority targets to support NewLimit's pipeline needs for targeting lipids. - Plan synthesis and purification for these modalities with scale and final purity in mind from the outset, delivering against agreed project timelines. - Build ionizable and targeting lipids for the tLNP platform using an SAR-based approach to guide the next design cycle rather than simply cataloging results. - Develop conjugation chemistry that links peptides, antibodies, nanobodies, and small-molecule ligands to lipid anchors, generating building blocks for cell- and tissue-selective delivery to support tLNP research and pipeline targets. - Turn in vitro and in vivo data from discovery teams into concrete structural hypotheses and revised molecules. - Present synthetic strategy, experimental results, and SAR conclusions, authoring protocols and technical reports.

Requirements - PhD in Chemistry, Pharmaceutical Chemistry, or a related discipline, plus 1-2 years of relevant work; or an MS with 5 years of focused lipid design experience for liposomal or lipid nanoparticle applications. - Strong skill set in the design and synthesis of new lipids or other delivery chemistries, performed personally rather than with a supervisor directing each step. - SAR-driven design, synthesis, purification, and characterization of ionizable lipids and PEG-lipid conjugates, using tools such as ChemDraw, Sci-Finder, Reaxsys, and AI-based SAR prediction tools for tLNP applications. - Working knowledge of conjugation chemistries for attaching targeting moieties such as peptides, antibodies, nanobodies, and small-molecule ligands, including linker design and the selection of suitable biorthogonal or site-specific handles. - Practical purification skills spanning normal- and reverse-phase chromatography and preparative HPLC. - Analytical characterization across LC-CAD, LC-UV, LC-MS/MS, and NMR (¹H, ¹³C, and ³¹P as needed), with the ability to deconvolute the data to produce well-characterized lipids.

Nice to have - Familiarity with lipid degradation pathways and impurity work such as N-oxides, hydrolysis products, and lipid-nucleic acid adducts, and how they affect potency and stability. - Solid-phase peptide synthesis, or antibody/nanobody modification experience. - Exposure to scale-up, CMC, or tech transfer to a CDMO. - Experience with data visualization and statistical analysis (R, Python, JMP)

Benefits NewLimit provides generous benefits so our team can remain focused on our mission: - Comprehensive Health, Dental, and Vision insurance. - 401(k) plan with company match. - Paid parental leave. - Industry-leading PTO: 20 days per year plus holidays. - On-site meals and snacks. Salary Range: $130,000 to $171,000.

Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.