Scientist II, Analytical Development

At Biogen, we are advancing science to deliver innovative therapies that transform patients’ lives. We are seeking a Scientist II to join our Analytical Development team as a Liquid Chromatography (LC) Subject Matter Expert (SME) and Analytical Project Lead. This role is pivotal, leveraging deep technical expertise in LC method development alongside leadership in analytical strategy across synthetics programs. Situated in Cambridge, MA, this lab-based position plays a crucial part in driving forward the development of synthetic drug substances and products, ensuring robust, stability-indicating methods. Your contributions will be vital to our mission, interfacing with various teams and shaping the analytical landscape of our drug development efforts.

You are enthusiastic about tackling complex analytical challenges to advance the development of small molecule therapeutics and oligonucleotides. You are motivated to learn new techniques and become a subject matter expert. You thrive both independently and collaboratively within a team setting, bringing a passion for scientific innovation and a commitment to excellence.

• Serve as the LC subject matter expert, leading method development, optimization, qualification, and troubleshooting (HPLC, UHPLC, LC-MS).
• Develop robust, stability-indicating methods for synthetic drug substances and products.
• Provide technical support to inform analytical strategy for development programs from early to late stage.
• Collaborate cross-functionally with CMC, formulation, process development, and quality teams.
• Provide oversight of analytical activities at CDMOs, including method validation, transfer, and lifecycle management aligned with regulatory expectations.
• Participate in mentoring and knowledge-sharing activities to support analytical capability building within the organization.
• Contribute to programs involving emerging modalities (e.g., oligonucleotides and peptides).

• Ph.D. with 0-3 years of relevant experience in pharmaceutical or biotech settings
• M.S. with 4+ years of relevant experience in pharmaceutical or biotech settings.
• BS with 6+ years of relevant experience in pharmaceutical or biotech settings
• Deep expertise in small molecule LC method development, with strong experience in HPLC/UHPLC and familiarity with LC-MS.
• Proven ability to lead analytical activities for drug development programs.
• Strong knowledge of ICH guidelines and experience working within regulated (GMP/GLP) environments.
• Excellent problem-solving, communication, and cross-functional collaboration skills.

• Experience with oligonucleotides and/or peptides.
• Advanced MS techniques (e.g., LC-MS/MS, HRMS).

Job Level: Management

The base compensation range for this role is: $117,000.00-$157,000.00

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about Biogen.