Process Development Engineer IV, Upstream

The Process Development Engineer IV supports upstream cell culture development for both early- and late-stage biotherapeutics programs. In this role, you will design and execute studies, generate and interpret data, and advance processes using a range of upstream technologies, including bench-top bioreactors, Ambr microscale bioreactors, shake flasks, WAVE bioreactors, and high-throughput purification systems.

You will work cross-functionally with upstream, downstream, and analytical teams to support program objectives, while contributing to technical documentation and leveraging process control systems such as DeltaV. This position also offers the opportunity to explore and apply emerging tools, including artificial intelligence and in silico approaches, to improve development speed and efficiency.

• Support the design and execution of upstream development studies across early- and late-stage programs

• Collaborate with upstream, downstream, and analytical teams as part of cross-functional development efforts

• Operate and troubleshoot cell culture systems, including bench-top bioreactors, Ambr, shake flasks, WAVE bioreactors, and high-throughput purification systems

• Utilize DeltaV or similar control systems to support process execution and data collection

• Maintain accurate and timely documentation in electronic laboratory notebooks

• Analyze process data, interpret results, and summarize findings to support development decisions

• Prepare technical reports, study summaries, and supporting documentation

• Learn and apply artificial intelligence and in silico tools to enhance process understanding and efficiency

• Bachelor’s degree with 5+ years, or Master’s degree with 3+ years of relevant experience in biochemical engineering, chemical engineering, biotechnology, biology, or related field

• Experience in biotherapeutics upstream process development

• Hands-on experience with upstream unit operations, including bioreactors (bench-top and Ambr), shake flasks, and WAVE systems

• Working knowledge of DeltaV or similar process control systems

• Solid understanding of upstream cell culture process development

• Ability to learn and apply new tools and technologies, including AI and in silico methods

• Strong attention to detail with the ability to work independently and collaboratively

• Proven ability to contribute to team objectives and support broader project goals

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.