Scientist/Senior Scientist for Pharmacology

- Design and develop animal models, execute in vivo experiments to evaluate the biological efficacy of novel therapeutic agents. - Independently lead in vivo service projects and preclinical studies, acting as Project Manager or Study Director. - Perform animal handling, tumor inoculation, drug administration via multiple routes, blood and tissue collection, tumor measurements, and PK/PD studies. - Design and execute internal model-building projects and characterize various humanized mouse models. - Provide troubleshooting support and technical guidance to junior associates. - Collaborate closely with the BD/Sales team for client project planning and technical discussions. - Present project results to clients and internal stakeholders; prepare scientific reports and summaries. - Mentor and facilitate the growth of junior research associates.

- Independently develop, validate, and perform a broad range of in vitro and ex vivo assays including:

- Immune cell profiling from blood and tissues. - Functional assays using primary cells (T cells, NK cells, macrophages). - Cytokine profiling, cytotoxicity, and apoptosis assays.

- Develop new assay technologies by researching scientific literature and adapting methodologies from collaborations and other internal teams. - Perform flow cytometry (FACS), ELISA, Western blot, qRT-PCR, and multiplex cytokine analyses. - Contribute to the design and support of in vivo pharmacology studies from an in vitro perspective. - Present research findings at internal meetings and contribute to external scientific discussions.

- PhD in pharmacology, immunology, cancer biology, or related biomedical field. - Extensive hands-on experience in animal models and preclinical in vivo pharmacology. - Proven skills in cell-based immunological assays including T cell activation, NK cell-mediated cytotoxicity, and macrophage functional assays. - Proficiency in PK/PD model establishment and analysis. - Expertise in flow cytometry, cytokine profiling (ELISA, qRT-PCR, multiplex assays), and immune cell isolation from tissues. - Experience with surgical procedures in rodents is highly desirable - Cross-functional knowledge across therapeutic areas is a plus. - Strong communication, organizational, and team collaboration skills with the ability to prioritize in a fast-paced environment. - Demonstrated ability to independently manage projects and work with cross-functional teams.