Postdoctoral Fellow, Protein Sciences, Kschonsak Lab

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come.

Creating a world where we all have more time with the people we love. That’s what makes us Genentech.

A Postdoctoral Fellow position is available for a highly motivated and independent candidate to join the laboratory of Dr. Marc Kschonsak in the Protein Engineering and Structural Biology Group within the Protein Sciences Department at Genentech. In this role, you will answer fundamental questions in membrane protein biology, focusing on the structural and functional mechanisms of transmembrane proteins, and their associated macromolecular signaling complexes

The Kschonsak Lab works on the biochemical and structural mechanisms of novel membrane proteins and their larger, endogenous signaling assemblies. We leverage a highly multidisciplinary approach—combining cryo-EM, endogenous purifications, and functional reconstitution—to understand how these complex systems operate across both recombinant and endogenous contexts.

In this role, you will have access to state-of-the-art structural biology and biophysical equipment and facilities. In addition, you will have opportunities to collaborate with other labs both within Genentech and in academia, and present your work at conferences.

• Ph.D. in a Relevant Field: You hold a Ph.D. with a proven track record of creativity, rigor, and success in structural biology, biochemistry, biophysics, or a related field, as exemplified by first-author publication(s) in high-impact journals.

• Protein Purification: Experience with expression and purification of challenging proteins is required

• Structural Biology Foundation: Experience with single-particle cryo-EM and/or X-ray crystallography sample preparation, data collection, and processing is required.

• Scientific Independence: You are independent and capable of designing, executing, and troubleshooting complex biochemistry and structural biology workflows to answer challenging biological questions.

• Collaborative Spirit: A strong collaborative spirit to work with others in a team to bring projects to fruition is needed.

• Communication Skills: Strong oral and written communication skills are required.

• Membrane Protein Expertise: Successful experience with the expression and purification of membrane proteins is highly desirable.

• Biochemical Functional Assays: Successful experience with the reconstitution of membrane proteins into lipid environments (e.g., liposomes, nanodiscs) and establishing functional transport or signaling assays.

• Endogenous Purifications: Experience in isolating endogenous complexes from tissues or cell lines.

• Cellular Assays: Experience with mammalian cell culture, heterologous expression, or cellular functional assays

For information about the Kschonsak lab, please go to:

https://scholar.google.com/citations?user=DRa8vIIAAAAJ&hl=de

https://www.gene.com/scientists/our-scientists/marc-kschonsak

The expected salary range for this position based on the primary location of South San Francisco California is $100,000 to $106,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.

Relocation benefits are available for this job posting.

Elevate your research career to new heights with Genetech’s Postdoctoral Program! Join a prestigious community of early career scientists and kick-start your journey toward becoming a scientific leader in biotechnology and bioengineering. With competitive salaries and fully funded research expenses, you can dedicate yourself to groundbreaking research that aligns with Genentech strategic ambitions.

The postdoc program is designed to empower recent Ph.D. graduates to conduct world-class research, publish in top-tier journals, and build a robust scientific network. By joining us, you will receive the mentorship and support necessary to develop into an independent scientist and leader.

The Genentech Postdoc Program provides access to world-class seminars, professional development workshops, and networking opportunities. Apply now to Genentech Postdoctoral Program and unlock your full potential!

#LI-PL1

#postdoc

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .