Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA. The successful candidate will be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates.
Excellent leadership, interpersonal, and organization skills as well as a high level of technical aptitude and creativity are required for success in this position.
- Be responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable, multi-step syntheses for the robust manufacture of small-molecule or oligonucleotide active pharmaceutical ingredients, spanning all phases of clinical development through to commercialization and launch
- Lead drug substance process development efforts and apply sound scientific judgement to drive multiple assets in a fast-paced environment via laboratory development, modeling, drug supply preparation, and technology transfer to third party manufacturing facilities
- Collaborate with materials discovery, process chemistry, analytical development, and formulation groups to improve the overall discovery/development process for definition and optimization of drug substance properties and performance across the clinical development spectrum
- Drive the adoption of process modeling within the department.
- Potentially lead projects, representing all aspects of pharmaceutical sciences
- Be at the forefront of industry best practices and promote innovation.
- Be vested in developing team members and technically mentoring junior-level scientists
- Influence departmental strategic direction
- Use excellent communication and interpersonal skills to influence stakeholders and interact, lead, and collaborate within an interdisciplinary team comprised of chemical engineers, organic, physical, and analytical chemists, materials and solid-state scientists, and formulation development personnel
- Experience leading a team of engineers/scientists in pharmaceutical process development
- Advanced knowledge of standard unit operations encountered in small molecule and/or Oligonucleotide drug substance process development inclusive of particle engineering, reaction kinetics, thermodynamics, and transport fundamentals
- Have demonstrated experience with modeling complex, physicochemical systems, data analysis, statistical design of experiments, QbD concepts, and fluency with common physical property and process modeling tools
- Demonstrated process scale up and regulatory dossier authoring.
- Experience with process development and problem solving in a matrix environment
- Strong communication skills and the ability to influence both stakeholders and team members
- A BS (+ 20 years), MS (+ 15 years) or PhD (+ 11 years) in Materials Science/Chemistry, or a closely related field, with relevant pharmaceutical materials development experience
- 5 years experience managing a team
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.