Associate Director, Heme Global Business Systems

About Vertex: At Vertex, we are relentless in our pursuit of transformative medicines to improve the lives of people with serious diseases. Building on a strong foundation of advancing therapies for cystic fibrosis, Vertex continues to expand its leadership across multiple disease areas, including cell and gene therapies, with the goal of delivering meaningful impact for patients worldwide.

Our Global Heme Cell and Gene Therapy (CGT) Operations team is at the forefront of innovation, commercial strategy, and operational excellence, driving the evolution of the global, cross-functional, "vein to vein” business process for CASGEVY, the only CRISPR-based autologous gene therapy approved for people living with Sickle Cell Disease and Transfusion dependent beta thalassemia.

We are seeking an Associate Director, Heme CGT Business Systems to lead global system strategy for CASGEVY. This critical role will be responsible for owning the strategy, roadmap and execution of the order management system and key commercial tools and processes, essential to delivering a vein-to-vein, autologous product.

As CASGEVY continues to scale across 9+ markets globally, the successful candidate will bring a strategic, analytical, and collaborative mindset, provide cross-functional leadership and drive alignment among international and US Heme Business Units, Manufacturing, Quality, and Technology teams involved in CASGEVY delivery.

• Own the product vision, roadmap, and prioritization for commercial capabilities supporting the Heme Franchise
• Partner with IT and regional stakeholders to translate business priorities into scalable tools, processes, and product enhancements
• Drive cross-functional alignment across global commercial teams, external manufacturing, quality, and other enabling functions to support business objectives, governance, and effective decision-making
• Work closely with Quality to ensure appropriate GxP processes, controls, and requirements are understood and adhered to across relevant systems, tools, and processes
• Lead change management efforts to support successful implementation, stakeholder engagement, and adoption of commercial capabilities across the organization
• Drive continuous improvement and ongoing optimization of commercial capabilities to enhance planning, execution, and operational effectiveness

• Demonstrated success working in cross-functional, matrixed organizations with multiple stakeholders
• Strong ability to simplify high-level concepts into actionable insights and advise on digital maturity, digital transformation and system integrations to the site leadership team
• Analytical problem-solving and strategic planning abilities

• Bachelor's degree in relevant discipline
• Typically requires 8 years of work experience leading the delivery of customer facing digital programs to promote products and services to external customers, or the equivalent combination of education and experience
• Experience in GxP regulated systems and related documentation, and GxP process and change management is highly preferred

Why Join Us? At Vertex, you’ll be part of a team that is transforming the lives of patients through innovative therapies.

We offer a dynamic and inclusive work environment where your contributions will make a meaningful impact.

How to Apply: If you are a driven professional with a passion for operational excellence and process optimization, we encourage you to apply. Please submit your resume and cover letter through our careers portal.