At Vertex, we are relentless in our pursuit of transformative solutions for patients with serious diseases. Our innovative approach to research and development has positioned us as a leader in the biotechnology industry. We are seeking a highly motivated and innovative Senior Scientist, Single-Cell Genomics to join a multidisciplinary research team focused on advancing the understanding of human disease biology and enabling translational research through state-of-the-art cellular and molecular profiling approaches.
The successful candidate will lead the design, execution, optimization, and interpretation of single-cell genomics and multi-omics workflows, with a primary emphasis on wet-lab experimental biology. This role will focus on implementation of 10x Genomics-based and related single-cell platforms to generate high-quality datasets from complex tissue and peripheral biological samples, including applications in immune cell profiling and disease-relevant contexts.
The ideal candidate will bring deep hands-on expertise in executing single-cell assays and the ability to partner closely with computational scientists and cross-functional research teams.
The candidate will contribute to developing mechanistic understanding of disease biology and support translational research, biomarker development, and therapeutic hypothesis generation.
This is an exciting opportunity for a scientist who is passionate about building and applying cutting-edge single-cell technologies to support target discovery, translational biology, and mechanistic investigation in a collaborative biotech environment.
- Process primary samples and cell-based systems for single-cell applications, including tissue dissociation, cell isolation, enrichment, counting, and viability assessment
- Generate high-quality libraries for transcriptomic, epigenomic, and/or immune profiling applications
- Perform sample and library QC using standard methods such as Qubit, TapeStation, and Bioanalyzer
- Perform end-to-end single-cell genomics and multi-omics workflows, including emerging modalities such as multiome and CITE-seq where appropriate, from sample acquisition through library preparation and sequencing
- Establish and refine SOPs, assay documentation, and experimental best practices
- Execute and troubleshoot assays using 10x Chromium and related technologies
- Troubleshoot technical issues across the workflow, including sample quality, library complexity, and sequencing performance
- Optimize workflows as needed to maximize sample quality, cell recovery, and reproducibility across studies
- Benchmark new methods and contribute to adoption of next-generation single-cell and multi-omics capabilities
- Coordinate with internal core groups or external vendors for sequencing, run tracking, and data generation
- Support or interface with flow cytometry and cell sorting activities where needed to enable downstream genomics workflows
- Collaborate closely with bioinformatics and computational biology teams to support interpretation of complex datasets and enable biologically meaningful insights
- Perform critical evaluation of assay and sequencing metrics, including read depth, mapping performance, cell recovery, and QC thresholds
- Deep hands-on expertise in single-cell genomics workflows, with particular experience in 10x Genomics platforms
- Strong wet-lab background in NGS library preparation, molecular biology, and complex sample processing
- Demonstrated ability to independently design, execute, troubleshoot, and optimize technically sophisticated experiments
- Experience with downstream computational analysis of single-cell datasets is not required but would be considered a significant advantage
- Strong attention to detail and commitment to high standards in experimental rigor, data quality, and documentation
- Effective communicator and collaborative scientist who works well in multidisciplinary, matrixed research environments
- PhD in Genomics, Molecular Biology, Chemical Engineering, Bioengineering, or a related discipline with 2+ years of relevant experience; or
- Master’s degree with 6+ years of relevant experience; or
- Bachelor’s degree with 8+ years of relevant experience
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.