Medical Director - Skin/IO

Shape the future of cancer care as a Medical Director, Skin/IO at Natera. In this strategic leadership role, you will provide medical expertise and scientific leadership across Natera’s oncology portfolio, with a focus on melanoma, cutaneous malignancies, and immunotherapy applications across solid tumors. You will collaborate with cross-functional teams in research, development, medical affairs, and commercial functions to ensure the scientific integrity and clinical adoption of Natera’s oncology testing solutions.

• Lead the clinical strategy and evidence generation for melanoma, non-melanoma skin cancers, and pan-tumor immunotherapy indications.

• Partner closely with clinical development, medical affairs, and commercial teams to translate emerging evidence into meaningful clinical practice applications.

• Collaborate with key opinion leaders (KOLs), cooperative groups, and academic investigators to validate and expand clinical use cases for ctDNA-based diagnostics in immuno-oncology.

• Provide field-facing education and strategic guidance to healthcare providers, payers, and advocacy organizations on clinical utility, interpretation, and impact of MRD and response monitoring in immune-treated populations.

• Identify and address barriers to adoption by aligning evidence generation, messaging, and stakeholder engagement with evolving standards of care and health system needs.

• Serve as the medical and scientific spokesperson for skin and immuno-oncology programs, communicating clinical utility, study data, and product value to external experts and stakeholders.

• Partner with commercial teams to develop educational resources, medical content, and scientific training for healthcare providers and internal teams.

• Provide scientific leadership during advisory boards, symposia, and investigator meetings.

• Represent Natera at national and international oncology and immunotherapy conferences, fostering relationships with key opinion leaders in melanoma and IO.

• Promote a culture of scientific rigor and innovation within the medical affairs and R&D organizations.

• Collaborate on clinical trial design, data analysis, and publication strategy related to ctDNA applications in melanoma and other immune-responsive solid tumors.

• Identify and cultivate academic and cooperative group partnerships to advance clinical validation and translational research in skin and pan-tumor immuno-oncology.

• Deep clinical knowledge of melanoma and cutaneous oncology, including evolving standards of care, targeted therapy, and checkpoint inhibitor use.

• Expertise in immunotherapy mechanisms, response kinetics, and biomarker development across multiple solid tumor types.

• Provide expert medical guidance on immunotherapy-specific diagnostic development and clinical implementation.

• Ability to engage across tumor types to support Natera’s broad oncology portfolio.

• Maintain awareness of emerging trends in liquid biopsy, precision medicine, and immune response monitoring.

• Work collaboratively with research, development, commercial, and medical affairs to align medical strategy with business objectives.

• Partner with regulatory and clinical operations teams to ensure compliance, data quality, and clinical relevance.

• MD. or D.O. degree with board certification in Medical Oncology (required).

• At least 5 years of experience in oncology, with clinical or research experience in melanoma, skin cancers, or immunotherapy (preferred).

• Strong publication or clinical trial background in immuno-oncology or translational oncology research (preferred).

• Associate or full Medical Director designation commensurate with experience.

• Ability to rapidly learn Natera’s molecular testing technologies and apply clinical judgment to evaluate and communicate their relevance.

• Strong written and verbal communication skills, including scientific presentation and education.

• Demonstrated success working cross-functionally with commercial, R&D, and clinical teams.

• Understanding of immuno-oncology trial design, translational endpoints, and regulatory considerations.

• Effective project management and ability to balance multiple high-impact initiatives.

• Collaborative mindset and ability to build consensus across functions.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: