Scientist/Senior Scientist

- Develop functional assays and pre-clinical models to measure endothelial cell function

- Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale

- Measure the impact of mRNA reprogramming medicines on endothelial cell function

- Engineer in vivo nucleic acid delivery methods for endothelial cells

- Analyze and interpret experimental data to drive pre-clinical decision making

- Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)

- Experience with primary cell isolation and functional characterization

- Experience working with mouse models (e.g. kidney, cardiovascular, or cognitive disease models)

- Experience with transgenic manipulation of primary cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)

- History of contributing to a drug development program at the pre-clinical or clinical development stage

- Experience leading the design and execution of pre-clinical studies in mouse models

- Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)

Salary Range: $130,000 to $180,000.

Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.