Principal Biologist/Senior Principal Biologist, Immune Aging

- Execute primary human immune cell experiments across multiple projects under the direction of the project lead, including isolation, culture, and functional characterization of T cells and other immune populations. - Design and run multiparameter flow cytometry and complementary molecular and cellular assays to interrogate target biology, including panel design, FACS sorting, multiplex cytokine quantification, Western blot, qRT-PCR, co-culture systems, and functional readouts of T cell activity and senescence. - Deliver decision-grade data through rigorous controls and pre-specified analysis plans; troubleshoot independently using evidence-based reasoning; and surface limitations and unexpected findings proactively. - Communicate results clearly through written summaries, presentation-quality figures, and team scientific reviews, while maintaining disciplined experimental records.

- Master's degree in Immunology, Cell Biology, Molecular Biology, or a closely related discipline, with 3+ years of industry research experience; or a Bachelor's degree with 5+ years of industry research experience. - Experience with immunoassays (ELISA, MSD, HTRF), multi-color flow cytometry (staining, acquisition, and analysis in FlowJo), and protein detection methods such as Western blotting.

- Working knowledge of cell and molecular biology concepts and a strong grasp of underlying assay principles. - Hands-on experience with cell lines, whole blood, and isolation and culture of primary human immune cells. - Demonstrated ability to operate and troubleshoot independently, with consistent, reproducible execution and strong technical communication. - Experience with cellular and biochemical assays in 96- and 384-well formats. - Research experience with small molecules, biologics, and/or genetic medicine modalities. - Experience with lentiviral and retroviral systems. - Light computational competence for flow data analysis (FlowJo) and basic data wrangling; deep computational expertise is not required.

Current US work authorization is required.

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Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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